【摘要】 MicroRNA是新近发现的一类调控性小分子RNA,通过降解靶基因mRNA或转录后抑制靶基因表达而发挥作用。近期的研究发现人血清中稳定存在一定水平的miRNA,并且血清miRNA表达谱的变化与多种肿瘤的发生、发展具有明确的相关性,说明血清miRNA可以作为肿瘤临床诊断和预后评估的分子标志物。更多还原

【Abstract】 MicroRNAsare small noncoding RNAsthat functionto regulate gene expression by post-transcription regulation or degradation mRNA of target gene.Recently,it has been shown that serum contains large amounts of stable miRNAs and that the serum miRNA expression profile can be used as a novel serum-based biomarker potentially offering more sensitive and specific tests than those currently available for early diagnosis of cancer and other diseases.更多还原