【摘要】 目的比较度洛西汀与帕罗西汀治疗社交焦虑障碍的疗效及不良反应。方法对86例社交焦虑障碍门诊及住院患者,随机分为两组,度洛西汀组和帕罗西汀组各43例,治疗8周,采用汉密尔顿焦虑量表(HAMA)和临床疗效总评量表,病情严重程度量表(CGI-SI)评定临床疗效,用治疗中出现的症状量表(TESS)评定药物不良反应。结果经过8周治疗,度洛西汀组和帕罗西汀组有效率分别为86.05和83.72两组疗效差异无统计学意义(P>0.05),两组不良反应发生率差异无统计学意义(P>0.05)。结论度洛西汀和帕罗西汀对社交焦虑障碍的疗效相当,不良反应较小,值得临床推广。更多还原

【Abstract】 Objective To investigate the efficacy and side effect of Dutoxetine in the treatment of social anxiety disorder compared to pParoxetine.Methods 86 cases were divided into two groups randomly,treated with Dutoxetine and Paroxetine respectively for 8 weeks.The Hamilton anxiety scale(HAMA),clinical global imp ression scale(CGI-SI) and treatment emergent symp tom scale(TESS) were used to assessthe therapeutic effect and side effect respectively.Results The effective power of dutoxetine group and paroxetine group were 86.05% and 83.72% respectively.There was no significant difference between two groups inimp rovement rate and side effect(P>0.05).Conclusion Dutoxetine is as effective as paroxetine for the treatment of social anxiety disorder with fewer side effect and worth clinical app lication.更多还原