【摘要】 目的研究60例颈动脉狭窄患者hs-CRP、Hcy含量变化。方法将2009年9月至2010年12月收入我院的60例颈动脉狭窄患者设为实验组,对照组62例均来自门诊健康体检者。采用荧光偏振免疫法和放射免疫比浊法分别测定Hcy、hs-CRP的浓度,采用颈动脉彩超、MRA或CTA检查颈动脉内膜厚度、有无斑块及狭窄。两组患者的年龄、性别等经统计学分析,差异无统计学意义(P>0.05),具有可比性。结果经测定实验组血浆Hcy的平均浓度为(20.4±7.6)μmol/L,对照组血浆Hcy的平均浓度为(10.4±1.2)μmol/L,经统计学分析,(P<0.01),差异具有统计学意义,即实验组血浆Hcy的水平高于对照组;实验组血清hs-CRP为(8.03±1.93)mg/L,对照组血清hs-CRP为(1.06±0.9)mg/L,经统计学分析,(P<0.01),差异具有显著性,即实验组血清hs-CRP的水平高于对照组。结论 hs-CRP、Hcy含量与颈动脉狭窄程度呈显著正相关,hs-CRP、Hcy可能成为脑血管疾病治疗的新靶点。更多还原

【Abstract】 Objective To study the change of hs-CRP,Hcy content of 60 cases of carotid artery stenosis, Hcy content. Methods experimental group were 60 cases of carotid artery stenosis from September 2009 to December 2010 were incomed, control group were 62 healthy persons from the clinic. fluorescence polarization immunoassay and radioimmunoassay were used to determine Hcy, hs-CRP levels, used Carotid ultrasound, MRA or CTA to examin carotid artery intima-media thickness, with or without plaques and stenosis. Both groups no age, sex and the statistical analysis had no significant difference (P>0.05).Results The experimental determination of the mean plasma Hcy concentration was (20.4±7.6)μmol/L, control group, the mean plasma Hcy concentration was (10.4±1.2) μmol/L, by statistical analysis, P<0.01, significant difference, that experiment had higher plasma Hcy levels; experimental serum hs-CRP was (8.03±1.93) mg/L, serum hs-CRP in control group was (1.06±0.9) mg/L, by statistical analysis, (P<0.01),there was significant difference, that is experimental serum hs-CRP levels higher. Conclusion hs-CRP, Hcy content and degree of stenosis are significantly correlated,they will be the new target to care the cranial vasculare diease.更多还原