【摘要】 目的研究元宝枫油的食用安全性。方法采用小鼠急性经口毒性试验、遗传毒性试验(Ames试验、小鼠骨髓细胞微核试验和小鼠精子畸形试验)及亚慢性毒性试验(大鼠90天喂养)对元宝枫油的食用安全性进行评价。结果元宝枫油对雌、雄性小鼠经口LD50均大于54 000 mg/kg BW,属无毒级;3项遗传毒性试验结果均为阴性;以10 800、5 400、2 700 mg/kg BW 3个剂量的样品液连续给大鼠灌胃90 d,实验期间动物生长发育良好,各项检测指标均未见异常。结论元宝枫油在本实验条件下为无毒物,未显示有急性、亚慢性毒性及遗传毒性。更多还原

【Abstract】 Objective To study the toxicological safety of Acer truncatum Bunge oil.Methods Acute toxicity and genotoxicity,including Ames test,micronucleus of born marrow and sperm abnormality in mice,and subchronic toxicity test in rats(90-day feeding test) were used to assess the safety of Acer truncatum Bunge oil.Results The oral LD50 of Acer truncatum Bunge oil in mice was more than 54 000 mg /kg BW,which belonged to an actual non-toxicity substance.The results of genotoxicity test were all negative.Rats were grown healthy and no abnormal indices were shown after test samples being orally given at the dosage of 10 800,5 400 and 2 700 mg /kg BW for 90 days.Conclusion Acer truncatum Bunge oil was nontoxic neither on genotoxicity test nor on subchronic toxicity test under the present condition.更多还原