【摘要】 目的:探讨中医优化方案对非酒精性脂肪性肝炎(NASH)临床疗效。方法:共收集4个分中心的NASH患者202例,随机分为治疗组(101例)和对照组(101例),两组均在健康教育、饮食运动基础上进行药物治疗,治疗组使用中药饮片基本方颗粒剂+加减方颗粒剂,1剂/日。对照组使用多烯磷脂酰胆碱(易善复)胶囊,456 mg/次,3次/日。两组疗程均为3个月,随访3个月,观察治疗后ALT,肝/脾CT值,TG,BMI及症状体征的变化。结果:治疗组在降低ALT,TG,BMI,提高肝/脾CT值,改善症状方面均明显优于对照组(P<0.05)。结论:中医优化方案治疗NASH,疗效明显优于烯磷脂酰胆碱胶囊,可作为中医诊疗方案在临床进一步推广。更多还原

【Abstract】 Objective:To investigate the effects of the Chinese medicine on non-alcoholic steatohepatitis(NASH).Method: Serum alanine aminotransferase(ALT),liver to spleen ratio triglyceride(TG),body mass index(BMI) and symptom signs of impact in patients were used for effecacy evaluation.In all,202 patients with NASH were collected from four sub-centers and randomly divided into treatment group(101cases) and control group(101 cases).The patients of treatment group were treated for 3 months with a daily traditional Chinese medicine,and the patients of control group were treated for 3 months with polyene phosphatidylcholine capsules(Essentiale),1 368 mg·d-1.Each patient was advised regular aerobic exercise and dietary modification.Result: The treatment group was significantly better than control group on improved serum ALT levels,liver to spleen ratios,TG,body mass index BMI and symptoms(P<0.05).Conclusion: The Chinese medicine for the treatment of NASH was better than Essentiale for improveing ALT levels,liver to spleen ratios,TG,BMI and symptoms.It can be promoted as a clinical treatment.更多还原