【摘要】 目的:研究益阴消渴滴丸中葛根素体外溶出度。方法:采用转蓝法,水为溶出介质,转速100 r·min-1。以葛根素为指标,考察滴丸在不同时间的累积溶出度,同时与原剂型益阴消渴胶囊比较。结果:葛根素在88.4～2 210μg与峰面积具有良好的线性关系(r=0.999 9),滴丸中葛根素在10 min时累积溶出率达到88.47%,胶囊剂10 min时累积溶出率仅为0.25%,120 min时为87.43%。结论:益阴消渴滴丸可提高难溶性有效成分葛根素的溶出度。更多还原

【Abstract】 Objective:To establish the method of the dissolubility of puerarin in Yiyin Xiaoke Pills.Method:Basket-stirring method was used for the determination of in vitro dissolution and HPLC method was applied to determine the accumulated dissolution rate of puerarin at the different time.Result:The calibration curve was linear in the range of 88.4-2 210 μg,(r = 0.999 9).The accumulated dissolution rate of puerarin in Yiyin Xiaoke pills reached 88.47% in 10min,while the accumulated dissolution rate of puerarin in capsule was only 0.25%.Conclusion:Yiyin Xiaoke pills can improve the dissolution rate of poorly soluble drugs of the kind of puerarin.更多还原