【摘要】 目的:探讨胆囊结石与非酒精性脂肪性肝病(Nonalcoholic fatty liver disease,NAFLD)的关系。方法:选择2006年4月7日-2010年1月9日湖南省人民医院体检个体共4 076例,排除过量饮酒、乙肝标志物阳性、严重感染及代谢综合征(Metabolicsyndrome,MS)资料不全者,共2830例纳入研究,其中1 367例在1～3年后再次体检。记录肝脏B超结果。结果:①体检人群中,胆囊结石患者合并NAFLD患病率明显高于非胆囊结石患者(43.20%vs 33.76%,P<0.05),NAFLD患者合并胆囊结石患病率亦明显高于非NAFLD患者(11.03%vs 7.67%,P<0.05);②随访1～3年后,NAFLD组(n=430)的胆囊结石发病率高于非NFALD组n(=834)(3.72%vs 1.68%,P<0.05),NAFLD发生胆囊结石的OR值为2.264(95%CI,1.094-4.683;P<0.05)。结论:①胆囊结石与NAFLD易合并存在。②NAFLD可增加胆囊结石患病风险。更多还原

【Abstract】 Objective:To investigate the relationship between nonalcoholic fatty liver disease(NAFLD) and cholecystolithiasis.Methods:Ultrasonography was used to diagnose NAFLD in 4 076 subjects attending routine health examination in the People’s Hospital of Hunan Province from April 2006 to January 2010.Total 2 830 subjects were enrolled in this study excluding those with excessive drinking,hepatitis B markers,and severe infection,and whose data to diagnose metabolic syndrome were missing.There were 1367 patients who received the routine health examination again during 3 years.The result of ultrasonography was recorded.Results: ①In the subjects undergoing routine health examination in People’s Hospital of Hunan Province,the prevalence of NAFLD in patients with cholecystolithiasis was significantly higher than that in those without cholecystolithiasis(43.20% vs 33.76%,P<0.05).Similarly,the prevalence of cholecystolithiasis in patients with NAFLD was also higher than that in those without NAFLD(11.03% vs.7.67%,P<0.05).②In a following up of 1 367 patients for 1 to 3 years,we found that the morbidity of cholecystolithiasis in patients with NAFLD(n=430) was significantly higher than that in those without NAFLD(n=430)(3.72% vs.1.68%,P<0.05).The presence of NAFLD was associated with an increased risk of cholecystolithiasis(OR=2.264;95% CI,1.094-4.683;P<0.05).Conclusion:①Cholecystolithiasis and NAFLD frequently coexist.②NAFLD may increase the risk of cholecystolithiasis.更多还原