【摘要】 目的研究甲状腺乳头状癌中D2-40,CK19,galectin-3,VEGF和EGFR的表达及其临床意义。方法应用免疫组化法检测38例甲状腺乳头状癌和12例甲状腺乳头状增生组织中D2-40,CK1 9,galectin-3,VEGF和EGFR的表达水平。结果 D2-4 0,CK1 9,galectin-3,VEGF和EGFR在甲状腺乳头状癌中的阳性表达率明显高于甲状腺乳头状增生组织(P<0.05);D2-40,VEGF,EGFR在甲状腺乳头状癌组织中有淋巴结转移组的表达高于无淋巴结转移组(P<0.05);CK19,galectin-3在甲状腺乳头状癌中的表达在有、无淋巴结转移组之间无统计学差异(P>0.05)。结论D2-40,CK19,galectin-3,VEGF及EGFR的检测有助于甲状腺乳头状癌与甲状腺乳头状增生的诊断和鉴别诊断;D2-40,VEGF和EGFR的表达与甲状腺乳头状癌淋巴结转移有关,对预测淋巴结的转移与否可能有帮助。更多还原

【Abstract】 Objective To investigate the expressions of D2-40,CK19,galectin-3,VEGF and EGFR in papillary thyroid carcinoma and their clinical significances.Methods The expressions of D2-40,CK19,galectin-3,VEGF and EGFR in 38 cases of papillary thyroid carcinoma and 12 cases of thyroid papillary hyperplasia were detected by immunohistochemical staining.Results The positive expression rates of D2-40,CK19,Galectin-3,VEGF and EGFR in patients with papillary thyroid carcinoma were all significantly higher than those in patients with thyroid papillary hyperplasia(all P<0.05).The expressions of D2-40,VEGF and EGFR in papillary thyroid carcinoma with lymph node metastasis were significantly higher than those without lymph node metastasis(P<0.05).The expressions of CK19 and galectin-3 showed no significant differences between the papillary thyroid carcinomas with and without lymph node metastasis(P>0.05).Conclusions The detection of D2-40,CK19,galectin-3,VEGF and EGFR is helpful to diagnosis and differential diagnosis of papillary thyroid carcinoma and thyroid papillary hyperplasia.The expressions of D2-40,VEGF and EGFR are associated with lymph node metastasis of papillary thyroid carcinoma,which may be useful for predicting whether or not there is cancer metastasis.更多还原