【摘要】 目的探讨淋巴结转移比率(MLNR)在预测淋巴结转移乳腺癌患者预后中的应用价值。方法回顾性分析94例接受改良根治术治疗的淋巴结转移乳腺癌患者的临床资料,并对患者生存情况及影响预后的相关因素进行分析。结果 94例患者随访时间为12~75个月,中位随访时间为64个月,5年生存率为72.34%(68/94)。总MLNR为0.31(486/1 553)。单因素分析显示原发肿瘤大小、淋巴结转移数目、ER状态、放疗与否和MLNR影响淋巴结转移乳腺癌患者的预后(P<0.05),而患者年龄、绝经与否、PR状态、内分泌治疗与否和组织学类型与预后无关(P>0.05)。多因素分析发现MLNR(OR=2.565,95%CI=1.043~6.309,P=0.040)和肿瘤大小(OR=2.220,95%CI=1.045~4.716,P=0.038)是影响淋巴结转移乳腺癌患者预后的独立因素。结论 MLNR是影响淋巴结转移乳腺癌患者的独立预后因素,且其预测效果比淋巴结转移数目更为准确和客观。更多还原

【Abstract】 Objective To evaluate the prognostic significance of metastatic lymph nodes ratio(MLNR) in patients with node-positive breast cancer.Methods The clinical data of 94 patients with node-positive breast cancer underwent modified radical mastectomy were retrospectively analyzed.The survival rate and prognosis factors of patients with complete follow-up data were assessed by log-rank test and multivariate regression analysis.Results The survival time of 94 patients ranged from 12-75 months,with median 64 months.The 5-year overall survival rate was 72.34%(68/94).The total MLNR was 0.31(486/1 553).Univariate analysis demonstrated that the survival was influenced significantly by tumor size,number of lymph node metastasis,MLNR,ER status,and radiotherapy or not(P<0.05),but not by patient’s age,menopause or not,PR status,endocrine therapy or not,and histological type(P>0.05).Multivariate analysis showed that MLNR(OR=2.565,95%CI=1.043-6.309,P=0.040) and tumor size(OR=2.220,95%CI=1.045-4.716,P=0.038) were independent prognostic factors for the patients with node-positive breast cancer.Conclusion MLNR is a major independent prognostic factor for the patients with node-positive breast cancer,which is more accurate than the number of metastatic lymph nodes in predicting the survival of patients with node-positive breast cancer.更多还原