【摘要】 目的观察卡前列素氨丁三醇(欣母沛)防治宫缩乏力性产后出血的临床疗效。方法选择98例有宫缩乏力性产后出血高危因素的产妇,随机分为治疗组和对照组。治疗组49例胎儿娩出后予缩宫素20 U静脉滴注+卡前列素氨丁三醇250μg宫肌注射;对照组49例胎儿娩出后予缩宫素20 U静脉滴注+缩宫素20 U宫肌注射。比较2组第三产程时间、产后2 h及24 h出血量、产后出血发生率、产后24 h血红蛋白下降值。结果治疗组第三产程时间(3.15±1.35)min,对照组(5.32±1.78)min(P<0.001);治疗组产后2 h出血量(326.6±186.2)mL、产后24 h出血量(389.6±182.4)mL、产后24 h血红蛋白下降值(11.52±3.23)g.L-1,均低于对照组(468.5±193.4)mL、(548.2±226.6)mL、(16.35±4.60)g.L-1,差异均有统计学意义(P<0.001);治疗组产后出血发生率明显低于对照组(P<0.05)。结论卡前列素氨丁三醇预防治疗宫缩乏力性产后出血效果显著,安全性好。更多还原

【Abstract】 Objective To investigate the effect of hemabate in postpartum hemorrhage caused by uterine atony.Methods A total of 98 women were randomly divided into 2 groups: a treatment group and a control group.The treatment group was given oxytocin 20 U iv.drip and hemmbate 250 μg into the uterine muscle after the delivery of fetus,while for the control group,oxytocin 20 U iv.drip and oxytocin 20 U into the uterine muscle after the delivery of fetus.The amount of bleeding within 2 and 24 h after the delivery,the length of the third stage of labor,and the incidence of postpartum hemorrhage were compared between the 2 group.Results The amount of bleeding within 2 and 24 h after the delivery,haematoglobin decrease 24 h after the delivery in the treatment group were significantly less than those in the control group(P<0.001).The length of the third stage of labor in the treatment group was shorter than that of the control group(P<0.001).The incidence of postpartum hemorrhage in the treatment group was significantly lower than that of the control group(P<0.05).Conclusion Hemabate is more effective and safe in reduction and prevention of atonic postpartum hemorrhage.更多还原