【摘要】 目的:评价双环醇片治疗氯丙嗪、氯氮平所致肝损害的临床疗效和安全性。方法:将115例使用氯丙嗪、氯氮平后所致肝损害的患者随机分为两组,治疗组58例,接受每日口服双环醇片75 mg治疗,对照组57例,采用保肝药物水飞蓟宾胶囊治疗,观察连续用药4周后的临床疗效和安全性。结果:在肝功能与综合疗效方面,两组均得到改善,但治疗组更为明显,差异有显著性(P<0.05,P<0.01);未发现与双环醇片有关的不良事件。结论:双环醇片治疗由氯丙嗪、氯氮平所致肝损害有效且安全。更多还原

【Abstract】 Objective:To analyze the efficacy and reliability of bicyclol on the treatment of hepatic Lesion induced by Chlorpromazine or Clozapine.Methods:115 patients with drug hepatitis were divided into two groups and received bicyclol orally 75mg daily or Silybin Capsules 210 mg daily for 4 weeks.The efficacy and reliability were observed.Results: Compared with pre-treatment,the liver function and synthetic curative effect were all improved in two groups.Bicyclol 75mg daily group is better(P<0.05,P<0.01).There were no obvious adverse events which were probably dealed with bicyclol by investigator’s estimation in the study.Conclusions: Bicyclol 75 mg tablets daily are effective and reliable on treating hepatic Lesion induced by Chlorpromazine or Clozapine.更多还原