【摘要】 目的:探讨非小细胞型肺癌组织中协同刺激分子B7-H3的表达及其与患者的病理参数、预后及CD3+T淋巴细胞的浸润程度的相关性。方法:收集2005年1月至2005年9月在苏州大学附属第四人民医院行手术切除术的非小细胞型肺癌患者组织标本87例,免疫组织化学的方法检测非小细胞型肺癌中协同刺激分子B7-H3的表达和CD3+T淋巴细胞的浸润程度。结果:协同刺激分子B7-H3在非小细胞型肺癌组织中高表达,该分子的表达与患者的年龄、性别、淋巴结的转移情况、肿瘤的大小、病理分型无相关性(P>0.05),但与患者的生存期呈负相关。且该分子在肺癌中的表达水平与浸润的T细胞呈负相关。结论:协同刺激分子B7-H3的表达在非小细胞型肺癌组织中诊断和预后判断中具有潜在的临床应用价值。更多还原

【Abstract】 Objective:To study the expression of B7-H3 in non-small cell lung cancer and its correction with pathoparameter,prognosis and the intensity of tumor infiltrating T lymphocytes.Methods:B7-H3 and CD3 expression was detected in 87 samples of human non-small cell lung cancer by immunohistochemical assay,which was collected from the Forth Affiliated Hospital of Soochow University(Wuxi,China) between Jan and Sep in 2005.Results:B7-H3 was expressed in the samples of human non-small cell lung cancer.This moelcular expression was not related with the patients age,sex,lymph node metastasis,tumor size and tissue type(P>0.05),but with the survival time and the intensity of tumor infiltrating T lymphocytes.Conclusion:Detection of B7-H3 expression in non-small cell lung cancer tissue is beneficial to the judgment of the prognosis of non-small cell lung cancer patients and the choice of treatment.更多还原