【摘要】 目的探讨老年高血压患者高敏C反应蛋白(hsCRP)与心、肾及血管靶器官损害的关系。方法选择心内科住院,年龄≥60岁的老年原发性高血压患者80例,检测hsCRP、晨尿白蛋白与尿肌酐的比值(ACR)、左心室重量指数(LVMI)及颈动脉内膜中层厚度(IMT)。结果 LVH组hsCRP水平和收缩压明显高于非LVH组,差异有统计学意义(P<0.05)。IMT增厚组hsCRP水平和收缩压明显高于正常IMT组,差异有统计学意义(P<0.05)。MAU组hsCRP水平明显高于无MAU组,差异有统计学意义(P<0.05)。相关分析显示,hsCRP与LVMI、IMT、ACR呈正相关(r值分别为0.504、0.431、0.384,均P<0.01)。hsCRP是LVMI、ACR及IMT的独立影响因素。结论 hsCRP与老年高血压患者靶器官损害程度呈正相关。更多还原

【Abstract】 Objective To study the relationship between target organ damage and plasma high-sensitivity C-reactive protein(hsCRP) in elder patients with hypertension.Methods 80 elder patients with essential hypertension were selected and determined on their plasma levels of hsCRP,urinary albumin/creatinine ratio(ACR),left ventricular mass(LVM) and carotid intima-media thickness(IMT).Results The hsCRP level in patients with left ventricular hypertrophy(LVH) were higher than that in subjects without LVH[(10.04±3.74) mg/L vs.(5.75±3.64) mg/L],P<0.05),the hsCRP in patients with high IMT were higher than that in subjects with normal IMT [(8.00±4.10) mg/L vs.(4.64±3.68) mg/L,P<0.05],the hsCRP in patients with micro-albuminuria(MAU) were higher than that in subjects without MAU [(8.09±4.10) mg/L vs.(4.72±3.48) mg/L,P<0.05].Correlation analysis showed that the plasma levels of hsCRP were positively related to LVMI,ACR and IMT(r=0.504,0.431,0.384,respectively,all P<0.01).Conclusion There is positive relationship between target organ damage and plasma hsCRP in elder patients with hypertension.更多还原