【摘要】 目的测定北社鼠对杀鼠灵的敏感性,为检验该鼠的抗药性提供参数。方法实验室做单个笼养无选择摄食试验:雌雄分开,随机分组,按5个不同食毒期供给浓度为0.025%的杀鼠灵毒饵;用Bliss计算机软件,计算不同食毒期与对应死亡率之间的关系。结果北社鼠对杀鼠灵的敏感性,性别之间差异无统计学意义(P_b>0.05,P_LFP50>0.05);故将雌雄数据合并计算,得毒力回归方程y=3.29+4.33x,LFP₅₀、LFP₉₅、LF₉₉及其95%置信限分别为2.48（1.97～3.13）、5.96（3.92～9.06）和8.56（4.65～15.78）d。结论按世界卫生组织推荐的以致死99%敏感靶标鼠的食毒期(LF₉₀)取整天数作为抗药性检验标准,山西省娄烦地区北社鼠对0.025%的杀鼠灵毒饵摄食期超过9 d存活即为抗性鼠。更多还原

【Abstract】 Objective To determine the susceptibility of Niviventer confucianus to warfarin.Methods Baits with 0.025% warfarin were randomly given in single-sex groups of five feeding periods.The time to mortality was analyzed using the Bliss software.Results There was no significant difference in the susceptibility between sexes(P_b>0.05,P_LFP50>0.05).The LFP₅₀, LFP₉₅ and LFP₉₉ of warfarin for N.confucianus were 2.48（1.97-3.13） days,5.96（3.92-9.06） days and 8.56（4.65-15.78） days, respectively.Conclusion According to the WHO-recommended LFP₉₉-based criteria for rodent warfarin resistance, N.confucianus surviving more than 9 days under exposure to 0.025%warfarin were classified into the resistant strains.更多还原