【摘要】 目的研究卵巢癌患者血清中HE4和CA125水平,为卵巢癌的临床诊断和鉴别诊断提供参考。方法分别用ELISA和电化学发光法检测121例妇女血清中HE4和CA125水平。其中78例盆腔肿瘤患者按术后病理结果分为卵巢癌组(n=27)和良性病变组(n=51);43例体检健康妇女作为正常对照组(n=43)。综合评价HE4和CA125联合检测的临床价值。结果卵巢癌组HE4和CA125水平分别为(581.5±445.7)PM/L和(817.5±534.4)U/L;良性病变组HE4和CA125水平分别为(51.4±22.9)PM/L和(84.5±78.9)U/L;正常对照组HE4和CA125水平分别为(36.7±12.0)PM/L和(18.9±9.3)U/L。HE4诊断卵巢癌的敏感性和特异性分别为66.7%和98.0%;CA125诊断卵巢癌的敏感性和特异性分别为88.9%和78.4%。结论血清HE4和CA125水平检测是诊断卵巢癌的良好指标,HE4单项检测的特异度优于CA125单项检测,二者联合检测可以提高诊断能力。更多还原

【Abstract】 Objective To investigate the expressions of serum HE4 and CA125 in the patients with ovarian carcinoma,and to serve as guides for diagnosis and differential diagnosis.Methods The levels of serum HE4 and CA125 in women were detected by ELISA and ELC.The patients were divided into two groups according to their postoperative pathology: the ovarian carcinoma group(n=27)and the benign group(n=51);43 healthy women were looked as normal control group.The clinical value was evaluated based on combined detection of HE4 and CA125.Results The levels of serum HE4 and CA125 in ovarian carcinoma group were 581.5±445.7 and 817.5±534.4,in the benign groups were 51.4±22.9 and 84.5±78.9,in the normal control group were 36.7±12.0 and 18.9±9.3.The sensitivity and the specificity in HE4 were 66.7% and 98.0%,in CA125 were 88.9% and 78.4%.Conclusion HE4 and CA125 are helpful biomarkers for ovarian carcinoma diagnosis and HE4 is better one.The diagnosis ability can be improved by combined with HE4 and CA125.更多还原