【摘要】 目的探讨JWA G723T多态性与食管癌易感性之间的关系。方法采用多聚酶链反应(polymerase chain reaction,PCR)和变性高效液相色谱法(denaturing high performance liquid chromatography,DHPLC)检测93例食管癌患者和200例对照者JWA基因G723T多态性并进行分析。结果病例组和对照组JWA G723T基因分布频度有显著差异(χ2=15.556,P=0.001)。与T/T基因型相比,T/G基因型发生食管癌的性别、年龄调整比值比上升到1.50(95%CI:1.14~1.95),G/G基因型发生食管癌的性别、年龄调整比值比上升到4.53(95%CI:1.62~12.65)。合并T/G和G/G基因型分析显示G等位基因发生食管癌的性别、年龄调整比值比上升到2.50(95%CI:1.50~4.16),显著增加食管癌的易感性(P<0.01)。结论 JWA G723T多态性与食管癌易感性相关。更多还原

【Abstract】 Objective To investigate the association between of JWA G723T polymorphisms and the risk of esophageal cancer.Methods We conducted a case-control study of 93 cases of esophageal cancer and population-based 200 controls in Jiangsu province,China.JWA G723T genotypes were identified by PCR and denaturing high performance liquid chromatography(DHPLC).Logistic regression was used to calculated odds ratios(OR) and 95% confidence intervals(95% CI).Results The frequencies of JWA G723T show significant difference between cases and controls(χ2= 15.556,P = 0.001).Relative to JWA 723 T / T genotype,the age and sex adjusted OR for T / G was 1.50(95% CI: 1.14-1.95),the adjusted OR for G / G was 4.53(95% CI: 1.62-12.65),and the adjusted OR for G allele was 2.50(95% CI: 1.50-4.16).The JWA G723T G allele showed moderately increased risk for esophageal cancer(P < 0.01).Conclusions There was a significant association between the JWA G723T polymorphisms and esophageal cancer susceptibility.更多还原