【摘要】 在生物转化研究中,获得对雷帕霉素具有转化作用的一株小单孢菌,经分类学研究鉴定为旱地小单孢菌(Micromonospora chersina)FIM03-712。该菌株转化雷帕霉素产生4个化合物,从转化发酵液中分离到一个分子量为900的转化产物,理化性质和波谱分析研究表明,该转化产物为14-去氧雷帕霉素。更多还原

【Abstract】 In the course of searching for new rapamycin derivatives by microbial conversion,a microorganism,which was able to biotransform rapamycin into four products,was obtained and classified as Micromonospora chersina FIM03-712.One conversion product from the converted broth of the strain was isolated and purified.By means of physico-chemical properties and spectral analyses,it was identified with 14-deoxorapamycin.更多还原