【摘要】 目的建立头孢硫脒在大鼠的生理药代动力学模型。方法按照血流限速理论,采用Matlab系统构建生理药代动力学模型程序;模型包括血液、心脏、肺、肾脏、肝脏、肠、胃、脾、胰腺、骨骼肌、皮肤、脂肪和甲状腺等生理相关性组织。生理性模型参数归纳自文献,组织-血液平衡分配系数等药物相关系数由实验测定。结果大鼠经脉给与头孢硫脒200mg/kg后,模型预测的药物浓度与试验观察值符合良好。结论建立了头孢硫脒在大鼠的生理药代动力学模型。更多还原

【Abstract】 Objective To develop physiologically based a pharmacokinetic(PBPK) model for cefathiamidine in rats.Methods A generic PBPK model,built in-house using MATLAB software,was employed for simulation of concentration-time profiles.The PBPK models consisted of pharmacologically relevant tissues(blood,heart,kidney,lung,gut,stomach,spleen,pancreas,liver,bone,muscle,skin,adipose and thymus) and used the assumptions of perfusion-rate limited tissue distribution of cefathiamidine.The required physiologic model parameters were obtained from the literature,whereas the pharmacokinetic(PK) parameters and the tissue-to-plasma partition coefficients were calculated using observed plasma and tissues data.Results The cefathiamidine model in rats yielded model-predicted concentration-time profiles that were in close agreement with the experimentally determined profiles after an intravenous cefathiamidine dose(200mg/kg).Conclusion PBPK models of cefathiamidine were developed in rats.Anti-virus activities of natural Polysaccharide maybe universal and deserve further study.更多还原