【摘要】 目的观察中药地黄、苏合香(地苏合剂)对早期肝性脑病大鼠脑皮层线粒体外周型苯二氮受体(PBRs)活性的影响。方法采用CCl4致化学性肝损伤大鼠模型,阳性药组给予乳果糖6 g/kg,治疗组分别给予不同剂量的地苏合剂,同位素法检测PBRs。结果模型组PBRs结合活性较对照组明显升高(P<0.01),中、高剂量组PBRs结合活性较模型组降低(P<0.05);模型组脑皮层线粒体PBRs的最大结合容量(Bmax)值较对照组明显升高(P<0.01),高剂量组较模型组明显降低(P<0.01)。结论地苏合剂可能通过降低早期肝性脑病大鼠脑皮层线粒体PBRs结合活性,减少神经损伤,从而延缓肝性脑病的发生、发展。更多还原

【Abstract】 Objective To assess the effects of Rehmannia and Storesin(RS) on peripheral-type benzodiazepine receptors(PBRs) in early hepatic encephalopathy(HE) rats.Methods CCl4 was used to induce the HE model.The benzodiazepine binding sites of PBRs in rats cortex were studied using the specific ligands PK11195.Lactulose was used in the positive medicine group,and the treatment groups received different dosages of RS.Results The specific binding and the Bmax value of PK11195 both significantly increased in the model group than in the control group(P<0.01).The specific binding decreased in the medium dosage group and the high dosage group than in the model group(P<0.05),and the Bmax value of PK11195RS-H decreased in the high dosage group than in the model group(P<0.01).Conclusion Rehmannia and Storesin is effective on early HE rats by decreasing the specific binding of PBRs,which could reduce the neural injury.更多还原