【摘要】 目的探讨肝气郁结证在特定脑区功能的改变。方法 10只Wistar大鼠采用慢性应激结合孤养方法制备肝气郁结证大鼠模型,分别于造模前后进行氟18脱氧葡萄糖(18F-FDG)PET正电子扫描,应用SPM2图像分析软件对造模前、造模后数据进行双样本t检验。结果葡萄糖代谢减低脑区(P<0.001)有左侧额叶、顶叶、下丘脑,双侧后扣带回,右侧前扣带回。葡萄糖代谢升高脑区(P<0.001)有左侧海马旁回、岛叶、颞叶、额叶,右侧基底核、丘脑。结论肝气郁结证可引起特定脑区的功能改变。更多还原

【Abstract】 Objective To explore the characteristics of brain function in rats with Stagnation of Liver-qi Syndrome.Methods Model of Stagnation of Liver-qi was made with chronic stress combined with isolated raising in 10 normal Wistar rats.They were scanned with posi-tron emission tomography(PET) before and after modeling.Data analysis was carried out using SPM(statistical parametric mapping 2) in MATLAB software.Results After modeling,the glucose metabolism decreased(P<0.001) in left frontal lobe,parietal lobe,hypothalamus;bilateral posterior cingulate;right anterior cingulate,while the glucose metabolism increased(P<0.001) in left parahippocampal gyrus,insu-la,temporal lobe,frontal lobe;right basal ganglia,thalamus.Conclusion The function of some cerebral areas can be changed undergoing Stagnation of Liver-qi Syndrome.更多还原