【摘要】 目的探讨人脑胶质瘤组织中转化生长因子β2(TGF-β2)、Smad3蛋白表达水平与患者预后的关系。方法应用免疫组化SP法检测80例人脑胶质瘤组织TGF-β2、Smad3蛋白表达水平,并分析其与患者无进展生存期及总生存期的关系。结果 TGF-β2蛋白和Smad3蛋白在不同级别胶质瘤之间表达具有显著性差异(P<0.05),其表达与病理级别呈正相关(r=0.545,r=0.570,P<0.01)。将所有患者分为TGF-β2或Smad3高表达组和低表达组,其无进展生存期和总生存期均有显著性差异(P0.05)。结论 TGF-β2、Smad3蛋白表达与胶质瘤发生及恶性程度相关;检测两者表达情况可为脑胶质瘤的临床诊治及预后判断提供依据。更多还原

【Abstract】 Objective To investigate the expressions of Transforming Growth Factor β2(TGF-β2) and Smad3 in human gliomas associated with pathologic grading.Methods The expressions of TGFβ2 and Smad3 protein were detected with SP immunhistochemistry in 80 human glioma specimens.The Kapan-Meier survival curves of progression-free survival time and overall survival time in different expression levels was compared with log-rank.Results The expression of TGFβ2 and Smad3 correlated with the pathological grading(r=0.545,r= 0.570,P<0.01).Both progression-free survival time and overall survival time were significantly different between low expression group and high expression group(P ≤ 0.05).Conclusion Both TGF-β2 and Smad3 correlate well with the occurrence and differentiation of human gliomas,which help for the diagnosis,treatment and prognosis judgment.更多还原