【摘要】 目的了解剖宫产围手术期抗菌药物的使用情况,为临床预防剖宫产切口感染合理用药提供依据。方法前瞻性调查2009年12月1日-2010年5月31日492例剖宫产产妇围手术期抗菌药物使用的种类、方法、用药天数、切口愈合和临床治疗效果等,将资料进行统计、分析。结果 492例剖宫产手术患者中围手术期抗菌药物使用率100.00%,抗菌药共6种,以头孢唑林为主,采用术中断脐后给抗菌药物1次,术后用药3~5 d,其中467例甲级愈合,切口甲级愈合率94.92%,10例乙级愈合,乙级愈合率2.03%;15例丙级愈合(切口感染),感染率3.05%;使用头孢唑林的199例患者中,切口甲级愈合率95.98%,使用头孢美唑的155例患者中切口甲级愈合率94.19%,使用头孢一代、二代和三代抗菌药物与切口愈合率,经统计学确切概率分析无关,差异无统计学意义。结论围手术期使用头孢唑林预防剖宫产切口感染,采用术中断脐后给药,术后3~4 d停药,合理有效。更多还原

【Abstract】 OBJECTIVE To learn perioperative use of antibiotics for cesarean section and provide the basis of rational use of antibiotics for preventing incision infection.METHODS A total of 492 cases from Dec 1,2009 to May 31,2010 were selected in a prospective study to observe antibiotics types,use,medication days,incision healing and clinic treatment effects.The data was analyzed statistically.RESULTS Antibiotics was used in all 492 cases.Cefazolin was used mainly in 6 types of antibiotics and was used after the interruption of umbilical cord for the first time,which was used for 3 to 5 days after operation.Healing rate of incision with grade A(467 cases) was 94.92%,with grade B(10 cases) was 2.03%,with grade C(15 cases)was 3.05%.Healing rate of incision with grade A(199 cases used Cefazolin) was 95.98%.Healing rate of incision with grade A(155 cases used Cefmetazole) was 94.19%.There was no significant difference between the usage of cephalosporin of first,second and third generation and healing of incision(P>0.05).CONCLUSION It is reasonable and effective to use Cefazolin after the interruption of umbilical cord for the first time and stop using 3-4 days later for preventing incision infection of cesarean section.更多还原