【摘要】 目的评价延长哌拉西林/他唑巴坦输注时间治疗革兰阴性杆菌感染的疗效及安全性。方法采用前瞻性、随机对照研究,根据哌拉西林/他唑巴坦的给药时间随机分为两组,即延长3 h输注治疗组和常规30 min输注治疗组,观察两组患者的临床疗效和不良反应。结果 66例患者完成治疗疗程;延长输注组35例,治疗有效率为68.6%,细菌清除率为42.8%;常规输注组31例,治疗有效率为41.9%,细菌清除率32.2%;两组间临床有效率差异有统计学意义,而细菌清除率差异无统计学意义。结论哌拉西林/他唑巴坦的延长输注方案优于常规输注方案。更多还原

【Abstract】 OBJECTIVE To evaluate the clinical efficacy and safety of extending the administration time of piperacillin/tazobactam in the treatment of Gram-negative bacteria infection.METHODS A prospective,randomized,controlled clinical study was conducted to compare the clinical efficacy and side-effects of prolonged infusion(3h) versus traditional infusion(30min) of piperacillin-tazobactam in patients with Gram-negative bacteria infection.RESULTS Thirty-five patients were enrolled in prolonged infusion group of piperacillin/tazobactam with an effective rate of 68.6 % and bacterial clearance rate of 42.8%.On the other hand,thirty-one patients were enrolled in traditional infusion group of piperacillin/tazobactam with an effective rate of 41.9% and bacterial clearance rate of 32.2%.There were significant differences between two groups on effective rate.There were no significant differences between two groups on bacterial clearance rate.CONCLUSION Prolonged infusion of piperacillin/tazobactam is superior to traditional regimens and should be recommended as empirical therapy against common Gram-negative bacteria.更多还原