【摘要】 目的探讨耐碳青霉烯类铜绿假单胞菌(PAE)及鲍氏不动杆菌(ABA)的临床分布与耐药特性,为临床抗感染治疗和合理使用抗菌药物提供依据。方法采用微量肉汤稀释法测定12种抗菌药物的最低抑菌浓度(MIC)。结果两年共分离耐碳青霉烯类PAE和ABA分别为261、117株,两者>80.0%来源于呼吸道标本,41.0%耐碳青霉烯类PAE和64.9%耐碳青霉烯类ABA来自于重症监护病房,耐碳霉烯类ABA的多药耐药性比PAE更为严重,该菌株除头孢哌酮/舒巴坦耐药率在23.1%外,其他均>70.0%,亚胺培南和美罗培南耐药率分别为93.1%和96.6%,而耐碳青霉烯类PAE对亚胺培南和美罗培南耐药性却差异较大,16.0%菌株对亚胺培南耐药,而对美罗培南敏感,其中可能存在不同的耐药机制。结论耐碳青霉烯类PAE和ABA的耐药率在不断上升,特别是多药耐药和泛耐药株的增多,因此应慎重、合理地使用碳青霉烯类抗菌药物,密切关注PAE和ABA耐药的发展,采取有效的感染控制措施。更多还原

【Abstract】 OBJECTIVE To investigate clinical characteristics of distribution and drug resistance of carbapenem-resistant Psedomonas aeruginosa and Acinetobacter baumannii.METHODS Broth microdilution method was employed to determine the minimum inhibitory concentration(MIC) of 261 isolated carbapenem-resistant P.aeruginosa and 117 isolated A.baumannii.RESULTS Separation of two years,carbapenem-resistant P.aeruginosa and A.baumannii,respectively 261,117,both more than 80.0% from respiratory tract specimens.41.0% of the carbapenem-resistant P.aeruginosa 64.9% of carbapenem-resistant A.baumannii were isolated from the intensive care ward.Carbapenem-resistant A.baumannii in multi-drug resistance than the carbapenem-resistant P.aeruginosa was more seriously,this strain except cefoperazone/sulbactam resistance rates of 23.1%,while the rest were above 70.0%,imipenem and meropenem resistance rates were 93.1% and 96.6%.Carbapenem-resistant P.aeruginosa resistant to imipenem and meropenem situation is quite different,16% of strains resistant to imipenem,while meropenem-sensitive,which may have different mechanisms of drug resistance.CONCLUSION Carbapenem-resistant P.aeruginosa and A.baumannii resistance rates on the rise,especially in multi-drug resistance and pan-resistant strains has increased.So be careful,rational use of carbapenem antibacterial drugs,pay close attention to P.aeruginosa and A.baumannii resistant to the development of effective infection control measures.更多还原