【摘要】 目的探讨HBeAg阳性慢性乙型肝炎(CHB)患者干扰素-α(IFN-α)疗效的影响因素。方法收集105例HBeAg阳性CHB患者,检测IFN-α治疗前及治疗12周时的ALT、HBV-DNA、HBsAg、HBsAb、HBeAg、HBeAb、HBcAb;分析年龄、性别、ALT基线水平、HBV-DNA基线水平对IFN-α疗效的影响。结果不同年龄段组间IFN-α疗效差异有统计学意义(P<0.05);ALT基线水平>120 U/L(<400 U/L),HBV-DNA基线水平<107拷贝/ml均能取得较好的疗效。结论 ALT基线水平、HBV-DNA基线水平、年龄可以作为预测IFN-α疗效的指标。更多还原

【Abstract】 OBJECTIVE To investigate the influence factors on the efficacy of IFN-α in HBeAg-positive CHB patients.METHODS Totally 105 HBeAg-positive CHB patients were treated with α-IFN,and ALT,HBV DNA level and HBsAg,HBsAb,HBeAg,HBeAb,HBcAb were determined before and after the therapy(12 weeks) to find out indexes for predicting the effect.RESULTS The efficacy of IFN-α therapy had significant difference in different ages(P<0.05).The baseline ALT level was higher than 120 U/L(P<0.05),and the baseline HBV-DNA level was lower than 107 copies/ml had more effective(P<0.05).CONCLUSION The efficacy of IFN-α is closely related to the levels of ALT,HBV DNA and age.更多还原