节点文献

乳腺癌组织TLR4蛋白表达及与细胞凋亡和增殖的关系

Expression of TLR4 and its relationship with cell apoptosis and proliferation in breast cancer

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 吕宝军张红雨王晓鸿苟新敏

【Author】 LV Bao-jun, ZHANG Hong-yu, WANG Xiao-hong, GOU Xin-min. Department of Thyroid and Breast Surgery, the Fifth Affiliated Hospital of SUN Yat-sen University, Zhuhai 519000, China

【机构】 中山大学附属第五医院甲状腺、乳腺外科中山大学附属第五医院肿瘤科中山大学附属第五医院病理科

【摘要】 目的探讨乳腺癌组织脂多糖受体(TLR4)的表达及其与细胞凋亡和增殖的关系。方法应用免疫组化法检测乳腺癌及相应癌旁组织TLR4、增殖细胞核抗原(PCNA)的表达,TUNEL法检测组织中细胞的凋亡。结果与癌旁组织比较,乳腺癌组织TLR4表达显著升高(P<0.05)。随着乳腺癌患者T分期、N分期、M分期和细胞凋亡增殖比的增加,乳腺癌组织TLR4的表达升高(P均<0.05),乳腺癌组织TLR4表达与癌组织分化程度无关。结论乳腺癌组织TLR4高表达,促进癌细胞的增殖,在乳腺癌的形成过程中起到了重要的作用。

【Abstract】 Objective To investigate the expression of TLR4 in breast cancer and their relationship with cell apoptosis and proliferation. Methods The expression of TLR4 and PCNA in cancer tissues and adjacent tissues were assessed by immunohistochemical method and the apoptosis was detected by the TUNEL method. Results The TLR4 expression in cancer tissues was significantly higher than that in adjacent tissues. Expression of TLR4 increased gradually with the progress of T stages, N stages, M stages and the ratio of apoptic index to proliferative index (P<0.05), but it had no correlation with histological grade. Conclusion TLR4 over expressed in breast cancer can promote cell proliferation, and play an important role in the pathogenesis of human breast cancer.

【关键词】 乳腺肿瘤TLR4PCNA细胞凋亡
【Key words】 Breast neoplasmTLR4PCNACell apoptosis
  • 【文献出处】 中华普通外科学文献(电子版) ,Chinese Archives of General Surgery(Electronic Edition) , 编辑部邮箱 ,2011年03期
  • 【分类号】R737.9
  • 【被引频次】9
  • 【下载频次】177
节点文献中: 

本文链接的文献网络图示:

本文的引文网络