【摘要】 目的探讨输卵管妊娠药物介入治疗的可行性、适应证、禁忌证。方法选择1998年10月至2009年12月在本院经阴道超声检查明确诊断为输卵管妊娠且病灶直径<5cm患者374例为研究对象。对其进行药物介入治疗,利用输卵管介入再通装置,于输卵管内一次性注入甲氨蝶呤(methotrexate,MTX)100mg,并观察患者血清β-人绒毛膜促性腺激素(human chorionic gonadotrophin,hCG)下降、阴道流血、病灶消失、输卵管通畅度、妊娠及腹痛消失等情况(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准,得到该委员会批准,并与受试者签署临床研究知情同意书)。结果 365例阴道超声检查示妊娠物内无胚芽及心导管搏动的输卵管妊娠患者,接受介入治疗获成功;另外9例妊娠物内可见胚芽及心导管搏动患者接受介入治疗失败后,改行手术治疗终止妊娠。结论对病灶直径<5cm、阴道超声示妊娠物内无胚芽及心导管搏动的输卵管妊娠患者,患侧输卵管内一次性注入甲氨蝶呤100mg介入治疗疗效肯定,并可能保留输卵管功能。更多还原

【Abstract】 Objective To investigate the feasibility,indication and contraindications of drug intervention therapy on tubal pregnancy(TP).Methods From October 1998 to December 2009,374 cases of tubal pregnancy whose lesion less than 5 cm were injected methotrexate(MTX)100 mg of drug intervention therapy by the tubal dredging device in a one-time,and then observed the effects of treatment.The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Affiliated Hospital of North Sichuan Medical College.Informed consent was obtained from all participants.Results A total of 365 cases of patients had no germ and heart duct in gravid were heald,other 9 cases of patients failed to germ and heart duct beat,and accepted operation of pregnancy termination.Conclusion It is effective on the tubal pregnancy whose lesion less than 5cm,with no germ and heart duct by injecting methotrexate 100mg,and may be retained the tubal function.更多还原