【摘要】 目的:探讨蜘蛛香环烯醚萜治疗肠易激综合征(IBS)的作用机制。方法:雄性SD大鼠60只,分为空白组、模型组、氟西汀组和蜘蛛香环烯醚萜高、中、低剂量组(24.92,12.46,6.23 mg.kg-1),各10只,以慢性应激加孤养的方法造模,观察蜘蛛香环烯醚萜对各组结肠、血清和下丘脑中5-HT和5-HIAA含量的影响。结果:模型组结肠、血清含量均显著上升,而下丘脑5-HT含量显著下降,5-HIAA和5-HT/5-HIAA变化则不太明显,蜘蛛香环烯醚萜各剂量组对结肠和血清中的5-HT有明显的降低作用,对下丘脑中5-HT则有升高作用。对5-HIAA的影响则无明显变化规律,而对结肠和血清中5-HT/5-HIAA则表现为降低作用。结论:蜘蛛香环烯醚萜改善IBS症状的机制可能与调节从胃肠到中枢的5-HT水平有关。更多还原

【Abstract】 Objective:To investigate the mechanism of iridoid from Valeriana jatamansi treating irritable bowel syndrome.Method: Sixty male SD rats were equally divided into 6 groups(2 controls,1 model and 3 treatment doses) with 10 rats per group.The test groups were administered with iridoid(24.92,12.46,6.23 mg·kg-1) while the control groups were administered with fluoxetine(2.5 mg·kg-1,positive control) or distilled water(negative control).The model was established by chronic stress and independent feeding.The influence of iridoid from V.jatamansi on 5-HT and 5-HIAA in colon,serum and hypothalamic were observed in all groups.Result: In the model group,the content of 5-HT in colon and serum increased significantly,but the content of 5-HT in hypothalamic decreased significantly.The content of 5-HIAA and the value of 5-HT/5-HIAA had no significant change.In three iridoid-treated groups,the content of 5-HT in colon and serum decreased,but the content of 5-HT in hypothalamic increased.The content of 5-HIAA had no significant change.The value of 5-HT/5-HIAA in colon and serum reduced.Conclusion: The mechanism of iridoid from V.jatamansi treating irritable bowel syndrome may be related to the regulation effect to the levels of 5-HT from Gastrointestinal to central nervous system.更多还原