【摘要】 目的:探讨中国人群CYP2D6*10等位基因对胃癌术后曲马多镇痛效果的影响。方法:70例胃癌根治术患者,手术结束前30min静脉注入负荷剂量曲马多100mg,随后采用持续背景剂量-PCA量的给药模式(曲马多10mg/mL、甲氧氯普胺0.3mg/mL)进行术后镇痛。全麻诱导后抽取血样,采用聚合酶链反应-限制性片断长度多态性方法分析患者CYP2D6*10基因多态性,根据不同CYP2D6基因型分为3组,比较不同基因组患者之间曲马多的用量。结果:CYP2D6*10等位基因频率为52.4%,不携带CYP2D6*10(I组)17例,CYP2D6*10杂合子(II组)26例,CYP2D6*10纯合子(III组)20例。48h曲马多用量,III组明显高于I组和II组,I组和II组之间差异无统计学意义。结论:在中国人群中,CYP2D6*10等位基因对曲马多镇痛效果有显著影响。更多还原

【Abstract】 Objective To investigate whether the CYP2D6*10 allele has an impact on the postoperative analgesia effect of tramadol in Chinese patients suffering from gastric cancer surgery.Methods Seventy gastric cancer patients suffering from gastrectomy were enrolled.After receiving a loading dose of 100 mg tramadol intravenously,patients could self-administer doses of 10 mg/mL tramadol plus 0.3 mg/mL metoclopramide via patient-controlled analgesia (PCA).Blood samples were collected after induction of anesthesia.The CYP2D6*10 polymorphism was analyzed by means of polymerase chain reaction-based restriction fragment length polymorphism(PCR-RFLP).Demographic data among groups with different genotypes were analyzed using analysis of variance.The total consumption of tramadol between the three genotype groups for 48 h was compared.Results The allele frequency of CYP2D6*10 is 52.4%:Patients were categorized into three groups according to the CYP2D6 genotype:patients without CYP2D6*10 (group I,n=17),patients with heterozygote for CYP2D6*10 (group II,n=26),and patients with homozygote for CYP2D6*10 (group III,n=20).The demographic data among the three groups were comparable.The total consumption of tramadol for 48 h in group III was significantly higher than that in other two groups,while it did not differ between groups I and II.Conclusions This study indicates that the CYP2D6*10 allele has significant impact on analgesia of tramadol in a Chinese population.更多还原