【摘要】 目的研究老年女性2型糖尿病患者骨量及骨代谢生化指标的变化。方法运用QCT测定42例正常老年女性以及31例确诊为2型糖尿病的老年女性患者的腰椎松质骨密度,检测糖化血红蛋白(糖尿病组)、胰岛素及C肽(空腹及餐后2h)、性激素、血钙、磷、总碱性磷酸酶、骨钙素及尿脱氧吡啶啉、尿钙、磷。结果①老年女性2型糖尿病组骨密度与年龄相匹配的对照组比较无显著差异(P>0.05);②老年女性糖尿病组Dpd及BGP水平均高于对照组(P<0.05),而雌二醇水平低于对照组(P<0.05)。结论老年女性2型糖尿病患者与正常老年女性相比骨密度无明显差异;血BGP及尿Dpd是老年女性2型糖尿病患者骨代谢紊乱的敏感指标。更多还原

【Abstract】 Objective To study the changes of bone mineral density and bone metabolic marker in elderly females with type 2 diabetes mellitus.Methods The trabecular bone mineral density of the lumbar spines in 42 elder female controls and 31 elder females with type 2 diabetes mellitus was measured using QCT.Hemoglobin A1c(HbA1c) in type 2 diabetes mellitus patients,insulin(Ins) and C-peptide(CP,fasting and 2h after meals),sex hormone,serum calcium(Ca) and phosphorus(P),alkaline phosphatase(ALP),bone gla protein(BGP),D-Pyridnoline(Dpd),urinary calcium(UCa) and phosphorus(UP) were measured.Results 1) No significant difference of BMD was found between elderly females with type 2 diabetes mellitus and age-matched controls(P>0.05).2) The levels of Dpd and BGP in elderly females with type 2 diabetes mellitus were higher than those of controls(P<0.05),but the estrogen level was lower(P<0.05).Conclusion No significant difference of BMD was found between elderly females with type 2 diabetes mellitus and normal elderly women.Serum BGP and urinary Dpd are sensitive markers of the bone metabolic disorders.更多还原