【摘要】 目的:探讨艾灸神阙穴对衰老的影响和作用机制。方法:将48只健康家兔随机分成8组,即Ⅰ组(空白对照组)、Ⅱ组(模型组)、Ⅲ组(神阙预防组)、Ⅳ组(神阙加足三里预防组)、Ⅴ组(神阙加命门预防组)、Ⅵ组(神阙治疗组)、Ⅶ组(神阙加足三里治疗组)、Ⅷ组(神阙加命门治疗组)。采用羟基脲片灌胃法对后7组进行肾阳虚家兔造模,从预防及治疗两方面观察艾灸对各组家兔血清超氧化物歧化酶(SOD)活性的影响。通过单用"神阙"与"神阙"加"足三里"、"神阙"加"命门"等穴位组合进行比较,观察不同穴位配伍对以上指标影响的差异。结果:造模后,Ⅱ、Ⅵ、Ⅶ、Ⅷ组出现明显的肾阳虚症状,SOD活性降低(均P<0.01);经艾灸治疗后,Ⅵ、Ⅶ、Ⅷ组肾阳虚症状明显改善(均P<0.01),出现明显的SOD活性升高(均P<0.01);Ⅲ、Ⅳ、Ⅴ组造模后出现少许肾阳虚症状,造模前后SOD活性改变不明显(均P>0.05);艾灸"神阙"、"神阙"加"足三里"、"神阙"加"命门"3种方法组间比较差异不明显(均P>0.05)。结论:艾灸"神阙"、"神阙"加"足三里"、"神阙"加"命门"3种穴位配伍均可以有效调节肾阳虚家兔血清SOD的活性,对肾阳虚家兔具有明显的预防及治疗作用;单用"神阙"穴和"神阙"加其他穴位相比,其作用差异不明显,艾灸"神阙"穴延缓衰老的机制与调节血清SOD活性关系密切。更多还原

【Abstract】 Objective To explore the influence of moxibustion at Shenque(CV 8) point on aging and its mechanism.Methods Forty-eight health rabbits were randomly divided into 8 groups,ie.group Ⅰ(normal control group),group Ⅱ(model group),group Ⅲ(prevention with moxibustion at Shenque(CV 8) group),group Ⅳ(prevention with moxibustion both at Shenque(CV 8) and Zusanli(ST 36) group),groupⅤ(prevention with moxibustion both at Shenque(CV 8) and Mingmen(GV 4) group),group Ⅵ(treatment with moxibustion at Shenque(CV 8) group),group Ⅶ(treatment with moxibustion both at Shenque(CV 8) and Zusanli(ST 36) group),and group Ⅷ(treatment with moxibustion both at Shenque(CV 8) and Mingmen(GV 4) group).The rabbit models of kidney-yang deficiency were created by pouring Hydroxyurea.The serum superoxide dismutase(SOD) activity was detected and the effect of the moxibustion from both prevention and treatment aspects were compared.And then the effect of different compatibility of acupoints was observed.Results After modeling,obvious symptoms of kidney-yang deficiency and decrease of SOD activity(all P<0.01) were found in groups Ⅱ,Ⅵ,Ⅶ and Ⅷ.After the moxibustion treatment,the syndromes of kidney-yang deficiency were significantly improved(all P<0.01) and SOD activities were increased obviously in groups Ⅵ,Ⅶ and Ⅷ(all P<0.01);a few syndromes of kidney-yang deficiency were found in groups Ⅲ,Ⅳ and Ⅴ after modeling,but with no significant changes of SOD activity(all P>0.05).There was no significant difference in three moxibustion treatment groups(all P>0.05).Conclusion Three acupoints compatibilities of moxibustion treatment can all regulate serum SOD activity in rabbits with kidney-yang deficiency effectively and have the significant effect both at prevention and treatment aspects and there is close relationship between their mechanisms on aging and regulating serum SOD activity.更多还原