【摘要】 目的:探讨壮医药线点灸疗法治疗围绝经期综合征的作用机制。方法:将30只家兔随机分为正常组、模型组、药线组、空线组和假手术组,每组6只。采用摘除卵巢去势建立围绝经期综合征模型。造模后药线组采用壮医药线点灸"脐周穴""下关元""肾俞""脾俞"等穴,每日1次,共治疗4周;空线组采用空线点灸与药线组相同穴位,其余各组不做干预处理,分别于治疗前后观察各组性激素的变化。结果:去势后血清雌二醇（E₂）水平模型组为（308.33±12.58）pmol/L、空线组为（303.43±10.57）pmol/L、药线组为（304.96±13.85）pmol/L,较正常组的（478.09±12.23）pmol/L、假手术组的（488.05±11.45）pmol/L下降（均P<0.01）。治疗后,E₂水平药线组为（338.92±11.23）pmol/L,有所上升（P<0.01）,高于模型组的（300.53±13.68）pmol/L、空线组的（309.74±13.59）pmol/L（均P<0.01）;药线组卵泡刺激素（FSH）为（58.90±5.29）U/L、黄体生成激素（LH）为（64.65±5.23）U/L,水平低于模型组的（65.41±5.19）U/L、（71.85±5.30）U/L（均P<0.05）。结论:壮医药线点灸疗法可提高去势家兔血清E₂水平及降低FSH、LH水平,这可能是其治疗围绝经期综合征的作用机制之一。更多还原

【Abstract】 Objective To explore the mechanism of medicated thread moxibustion of Zhuang medicine（MTMZ） in treating perimenopausal period syndrome.Methods Thirty rabbits were randomly divided into a normal group,a model group,a medicated thread group,a no-medicated thread group and a sham operation group,6 cases in each group.The model of perimenopausal period syndrome was established by ovariectomizing the ovary.The medicated thread group was treated with MTMZ at"Qizhou"acupoint（Extra）,"Xiaguanyuan"（Extra）,"Shenshu"（BL 23） and"Pishu"（BL 20）,etc.,once each day for 4 weeks.The no-medicated thread group was treated with no-medicated thread moxibustion at the same acupoints,and there is no treatment in the other groups.The changes of hormone level in each group before and after the treatment were observed.Results After ovariectomizing the ovary,the serum estradiol（E₂） in the model group[（308.33±12.58） pmol/L],the medicated thread group[（304.96±13.85）pmol/L]and the no-medicated thread group[（303.43±10.57）pmol/L]were lower than that in the normal group[（478.09±12.23）pmol/L]and the sham operation group[（488.05±11.45）pmol/L]（all P<0.01）.After treatment,the E₂ level in medicated thread group[（338.92±11.23）pmol/L]was higher than before（P<0.01） and that in the model group[（300.53±13.68）pmol/L]and the no-medicated thread group[（309.74±13.59）pmol/L] （both P<0.01）,and the serum follicle stimulating hormone[FSH,（58.90±5.29）U/L]and luteinizing hormone [LH,（64.65±5.23）U/L]were lower than those in the model group[（65.41±5.19）U/L]、[（71.85±5.30）U/L] （both P<0.05）.Conclusion MTMZ can increase the serum E₂ and reduce the serum FSH and LH in ovariectomized rabbits,and this may be one of the mechanisms of MTMZ for treatment of perimenopausal period syndrome.更多还原