【摘要】 目的:研究血塞通注射液连续多次给药后对大鼠CYP2D1酶的影响。方法:12只大鼠采用自身对照的实验方法,先后单用探针药物(氢溴酸右美沙芬10mg.kg-1)以及合用血塞通注射液(180mg.kg-1)7d,采用HPLC法测定血浆中右美沙芬的浓度,观察血塞通注射液对大鼠CYP2D1酶的影响。结果:右美沙芬单用以及与血塞通注射液合用的主要药动学参数分别为t1/2β(153.1±25.4)min,(179.5±48.6)min(P<0.05);AUC0→t(85.6±9.9)mg.L-1.min,(105.2±21.2)mg.L-1.min(P<0.01),CL(0.098±0.012)mL.kg-1.min-1,(0.080±0.016)mL.kg-1.min-1(P<0.01)。结论:血塞通注射液对大鼠CYP2D1酶有明显抑制作用。更多还原

【Abstract】 OBJECTIVE To study the effect of the continuous administration of Xuesaitong injection on the activity of CYP 2D1 in rats in vivo.METHODS Using self-control in this study,12 rats administrated with dextromethorphan hydrobromide(10 mg·kg-1)singly and then combination with Xuesaitong injection(180 mg· kg-1)7d,the plasma concentration of dextromethorphan was determined by HPLC.The effect of Xuesaitong injection on the activity of CYP2D1 was evaluated in rats.RESULTS The main pharmacokinetic parameters of dextromethophan after single administration and in combination with Xuesaitong injection were as follow: t1/2β(153.1±25.4) min,(179.5±48.6) min(P<0.05);AUC0→t(85.6±9.9) mg·L-1·min,(105.2±21.2) mg·L-1·min(P<0.01);CL(85.6±9.9) mg·L-1·min,(0.098±0.012) mL·kg-1·min-1,(P<0.01).CONCLUSION Xuesaitong injection have marked inhibition on CYP2D1 activity in rats.更多还原