【摘要】 目的:研究右美沙芬咀嚼胶新型给药系统体外释放行为。方法:建立了新型右美沙芬咀嚼胶给药系统中药物释放的测定法;运用溶出仪法、冲压法和夹剪法进行体外释放实验,采用拟合因子法比较各评价方法。结果:3种方法测得的释放行为差异无显著性,优选溶出仪法进行测定。结论:溶出仪法、冲压法和夹剪法均可用于测定咀嚼胶新型给药系统的体外释放,优选溶出仪法。更多还原

【Abstract】 OBJECTIVE To study in vitro drug release behavior of dextromethorphan chewing gum medicine drug delivery system.METHODS To establish the assay method of dextromethorphan in the chewing gum medicine drug delivery system.The in vitro release of DH-CGP was determined.Fitting factors method was adopted for evaluating the effects of three different release methods.RESULTS The release characters of DH-CGP were not influenced by three different release methods significantly,but the way of the release equipment is more operability than the other way.CONCLUSION The release way of the release equipment could preferably simulate the in vitro situation in three preparations,and with a good reproducibility.更多还原