【摘要】 目的建立一种采用分子烙印技术识别分离甲磺酸伊马替尼及其类似物的方法。方法以酪氨酸激酶抑制剂甲磺酸伊马替尼为模板,采用本体聚合制备分子烙印聚合物,采用固相萃取等方法,以平衡吸附量为指标对其分子识别能力进行考察。结果分子烙印聚合物对甲磺酸伊马替尼有特异性吸附能力。结论本实验制备的分子烙印聚合物可以用于从天然产物识别分离甲磺酸伊马替尼类似物。更多还原

【Abstract】 OBJECTIVE To establish a selective isolation method of imatinib mesylate using molecular imprinting technology.METHODS The molecular imprinted polymer(MIP) was synthesized by bulk polymerization using imatinib mesylate as the template.The MIP was investigated for its recognition of imatinib mesylate by equilibrium absorption and solid-phase extraction.RESULTS The MIP had specific absorbability to Imatinib mesylate.CONCLUSION The MIP prepared in the study can be used for selective recognition and isolation of imatinib mesylate analogues from natural products.更多还原