【摘要】 目的评价2009-2010年上海市甲型H1N1流行性感冒疫苗(甲流疫苗)的免疫学效果。方法以公安人员、中小学生、医务人员这三类重点人群作为免疫学评价的对象,采用分层抽样的方法在上海市4个区县抽取公安人员110人,中小学生146人,医务人员306人,于甲流疫苗接种前和接种后5~6周分别采集外周静脉血,检测甲型H1N1流感(甲流)抗体水平,进行甲流疫苗免疫学效果评价。结果总体上,甲流抗体阳性率由接种前34.9%提高到98.9%,抗体几何平均滴度(GMT)由接种前1∶17提高到1∶351,抗体≥4倍增长率为85.6%。结论 2009年上海市大规模人群接种的甲流疫苗具有良好的免疫学效果。更多还原

【Abstract】 Objective To evaluate the effectiveness of influenza A(H1N1) virus split vaccine on a mass-vaccination program.Methods A stratified sampling method was applied to select 110 public security staff,146 elementary and high school students and 306 health care professionals.All participants were tested for influenza A antibody levels before and in 5-6 weeks after the vaccination of influenza A(H1N1).Results The positive rate of influenza A(H1N1) influenza antibody increased from 34.9% to 98.9% and the average titer of antibody increased from 1:17 to 1:351 for positive specimens after the vaccination.A four-fold increase of influenza antibody was observed in 85.6% of post-vaccination specimens.Conclusion The influenza A(H1N1) vaccine demonstrated good immunological effectiveness.更多还原