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2009年上海市甲型H1N1流感疫苗大规模人群接种免疫学效果评价

Evaluation of influenza A(H1N1) vaccination effectiveness in Shanghai,2009

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【作者】 顾宝柯于淼陈健蔡华袁政安王丹陈昕赵根明刘杰张涛

【Author】 GU Bao-ke,YU Miao,CHEN Jian,CAI Hua,YUAN Zheng-an,WANG Dan,CHEN Xin,ZHAO Gen-ming,LIU Jie,ZHANG Tao.Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China

【机构】 上海市疾病预防控制中心复旦大学公共卫生学院公共卫生安全教育部重点实验室上海市卫生局

【摘要】 目的评价2009-2010年上海市甲型H1N1流行性感冒疫苗(甲流疫苗)的免疫学效果。方法以公安人员、中小学生、医务人员这三类重点人群作为免疫学评价的对象,采用分层抽样的方法在上海市4个区县抽取公安人员110人,中小学生146人,医务人员306人,于甲流疫苗接种前和接种后5~6周分别采集外周静脉血,检测甲型H1N1流感(甲流)抗体水平,进行甲流疫苗免疫学效果评价。结果总体上,甲流抗体阳性率由接种前34.9%提高到98.9%,抗体几何平均滴度(GMT)由接种前1∶17提高到1∶351,抗体≥4倍增长率为85.6%。结论 2009年上海市大规模人群接种的甲流疫苗具有良好的免疫学效果。

【Abstract】 Objective To evaluate the effectiveness of influenza A(H1N1) virus split vaccine on a mass-vaccination program.Methods A stratified sampling method was applied to select 110 public security staff,146 elementary and high school students and 306 health care professionals.All participants were tested for influenza A antibody levels before and in 5-6 weeks after the vaccination of influenza A(H1N1).Results The positive rate of influenza A(H1N1) influenza antibody increased from 34.9% to 98.9% and the average titer of antibody increased from 1:17 to 1:351 for positive specimens after the vaccination.A four-fold increase of influenza antibody was observed in 85.6% of post-vaccination specimens.Conclusion The influenza A(H1N1) vaccine demonstrated good immunological effectiveness.

  • 【文献出处】 中国预防医学杂志 ,Chinese Preventive Medicine , 编辑部邮箱 ,2011年06期
  • 【分类号】R186
  • 【被引频次】5
  • 【下载频次】206
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