【摘要】 目的:了解我院抗肿瘤药致不良反应(ADR)发生的特点及一般规律。方法:对我院2009年1月-2011年4月上报的涉及抗肿瘤药的281例ADR报告进行收集、汇总、分析。结果:281例ADR共涉及抗肿瘤药52种,涉及最多的给药途径为静脉滴注,有260例(占82.02%);其中40岁以上中老年患者较多,有248例(占88.26%);ADR累及器官或系统最多的为心脑血管系统,有172例(占25.04%);ADR报告排名前13位药物的发生频次占总数的64.35%,其中奥沙利铂的ADR发生率居首位。结论:我院作为肿瘤专科医院更应加强抗肿瘤药致ADR的监测工作,规范抗肿瘤药过敏的常规预处理。更多还原

【Abstract】 OBJECTIVE:To investigate the characteristics and regularity of adverse drug reactions(ADR)of antineoplastic drugs in our hospital.METHODS:281 ADR cases reported by our hospital from Jan.2009 to Apr.2011 were collected and summarized for analysis.RESULTS:A total of 281 ADR cases involved 52 kinds of antineoplastic drugs.Intravenous dripping was main route of administration(260 cases,82.02%).88.26% occurred in patients older than 40(248 cases).ADR mostly manifested as lesions of cardiovascular system in 172 cases,accounting for 25.04%.The incidence of top 13 drugs in ADR list accounted for 64.35% of the total,in which oxaliplatin ranked the first.CONCLUSION:ADR monitoring of antineoplastics drugs should be strengthened in cancer hospitals and the anti-allergic pretreatment of antineoplastics drugs should be standardized.更多还原