【摘要】 目的:评价4种抗抑郁药治疗抑郁症的经济性的优劣。方法:采用循证医学方法收集氟西汀、帕罗西汀、文拉法辛和西酞普兰治疗抑郁症的药物经济学评价文献,提取各文献中有关成本-效果比的数据,综合分析两两药物间的经济性。结果:氟西汀的经济性与帕罗西汀差异无统计学意义;文拉法辛的经济性显著优于氟西汀;西酞普兰的经济性与氟西汀差异无统计学意义;文拉法辛的经济性显著优于帕罗西汀;西酞普兰的经济性与帕罗西汀差异无统计学意义;文拉法辛的经济性显著优于西酞普兰。结论:文拉法辛治疗抑郁症的经济性最优,与其他3种药物比较差异均具有统计学意义,西酞普兰、氟西汀和帕罗西汀之间差异则无统计学意义。更多还原

【Abstract】 OBJECTIVE: To evaluate the economics of 4 kinds of antidepressants in the treatment of depression. METHODS: Using the method of evidence-based medicine, literatures on fluoxetine, paroxetine, venlafaxine, and citalopram in the treatment of depression were collected to extract all the data related to cost-effectiveness ratio and compare economical efficiency of drugs. RESULTS: There was no significant difference in economical efficiency of fluoxetine and paroxetine; Venlafaxine was significantly better than economical efficiency of fluoxetine; The economical efficiency of citalopram and fluoxetine had no significant difference; The economical efficiency of venlafaxine was significantly better than paroxetine. CONCLUSION: Venlafaxine is the most economical treatment for depression, which has significant differences compared with the other three drugs, and there is no significant difference between citalopram, fluoxetine and paroxetine.更多还原