【摘要】 目的:研究卡维地洛与贝那普利联合治疗老年慢性心力衰竭(CHF)的临床疗效与安全性。方法:选择我院2009年1月-2010年1月住院的82例CHF患者,随机分为2组。观察组41例采用卡维地洛与贝那普利联合治疗,对照组41例采用贝那普利治疗。观察2组的临床疗效及治疗前后左室收缩末内径(LVESD)、左室舒张末内径(LVEDD)及左室射血分数(LVEF)水平的变化。结果:观察组治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05)。2组治疗后LVEDD、LVESD及LVEF都较治疗前有明显改善,差异有统计学意义(P<0.05)。观察组治疗后LVEDD、LVESD及LVEF改善状况均明显优于对照组,差异有统计学意义(P<0.05)。2组不良反应比较,差异无统计学意义(P>0.05)。结论:卡维地洛与贝那普利联合应用治疗老年CHF,具有良好的协同作用,能够明显提高临床疗效,改善左心室功能。更多还原

【Abstract】 OBJECTIVE:To observe clinical efficacy and safety of carvedilol combined with benazepril in the treatment of chronic heart failure(CHF).METHODS:82 cases of CHF in our hospital from Jan.2009 to Jan.2010 were randomly divided into 2 groups.41 patients in observation group were treated with carvedilol and benazepril,and control group was given benazepril alone.The clinical efficacy,the change of left ventricular end systolic diameter(LVESD),left ventricular end diastolic diameter(LVEDD) and left ventricular ejection fraction(LVEF) levels of 2 groups were observed before and after treatment.RESULTS:The total effective rate of observation group was significantly higher than that of control group(P<0.05).LVEDD,LVESD and LVEF were significantly improved after treatment,the difference was statistically significant(P<0.05).The improvement of LVEDD,LVESD and LVEF in observation group were significantly better than in control group,the difference was statistically significant(P<0.05).There was no significant difference in adverse drug reactions(P>0.05).CONCLUSION:Carvedilol combined with benazepril has a good synergistic effect on elderly heart failure,can significantly improve clinical efficacy and improve left ventricular function.It is worthy of clinical application.更多还原