【摘要】 目的分析轻型再生障碍性贫血(MAA)患儿的转归。方法回顾性分析1996年1月-2009年1月在我院治疗的43例MAA患儿的临床资料。所有患儿诊断后均按照患儿家长意愿选择以下三种治疗方案中的一种:中药组(Ⅰ组,3例):只接受中药治疗;雄激素+中药组(Ⅱ组,10例):接受中药联合康力龙[0.1 mg/(kg.d)]治疗;环孢菌素A+雄激素+中药(Ⅲ组,30例):接受环孢菌素A、康力龙[0.1 mg/(kg.d)]及中药治疗。中位随访时间为42个月(5～116个月)。结果在随访时间内,Ⅰ组3例患儿中仅有1例获得部分缓解,1例在随访73个月时进展为重型再生障碍性贫血(SAA),1例无效;Ⅱ组10例患儿中有3例(30%)获得部分缓解,其余7例(70%)均无效,无一例进展为SAA;Ⅲ组30例患儿中有9例(30%)获得完全缓解,5例(17%)获得部分缓解,1例(3%)在随访至11个月时进展为SAA,其余15例(50%)无效。结论早期给予干预的MAA患儿进展为SAA比率较低。更多还原

【Abstract】 Objective To investigate the incidence and progression of mild aplastic anemia(MAA).Methods Forty-three children with MAA treated in our hospital from January of 1996 to January of 2009 were reviewed retrospectively.Three patients(groupⅠ) were selected to receive Chinese herbal drugs only.Ten patients(groupⅡ) were selected to receive Chinese herbal drugs and stanozolol,while the rest(groupⅢ) were selected to receive Chinese herbal drugs combined with stanozolol and cyclosporin-A.Results At a median follow-up of 42 months(range from 5 to 116 months),one patient in group I developed to SAA and one had a partial remission;three patients in group Ⅱ(30%) had a partial remission and the rest(70%) had no effect;nine patients in group Ⅲ(30%) got a complete remission,five patients(17%) had a partial remission,one(3%) developed to SAA,and the rest(50%) had no effect.Conclusions Patients with MAA given early intervention had lower ratio to develop SAA.更多还原