【摘要】 目的探讨HBeAg阴性慢性乙型肝炎(CHB)患者干扰素-α(IFN-α)早期疗效的影响因素。方法收集40例HBeAg阴性CHB患者,检测IFN-α治疗前及治疗12周时的ALT、HBV DNA、HBsAg、HBsAb、HBeAg、HBeAb、HBcAb;分析年龄、性别、ALT基线水平、HBV DNA基线水平对IFN-α疗效的影响。结果性别组间、不同年龄段组间、不同ALT基线水平组间、不同HBV DNA基线水平组间比较IFN疗效差异无统计学意义(P>0.05)。结论性别、年龄、ALT基线水平、HBV DNA基线水平、年龄不可以作为预测IFN-α治疗HBeAg阴性慢性乙型肝炎患者的早期疗效指标。更多还原

【Abstract】 Objective To investigate the influence factors on the efficacy of IFN-α in HBeAg-nagetive CHB patients.Method 40 HBeAg-nagetive CHB patients were treated with α-IFN;The ALT,HBV DNA levels and HBsAg,HBsAb,HBeAg,HBeAb,HBcAb were determined before and after the therapy(12 weeks) to find out the indexes for predicting the effect.Result The efficacy of IFN-α therapy had no significant difference in sexs,different ages,the baseline ALT levels and the baseline HBV DNA levels(P>0.05).Conclusion The initial efficacy of IFN-α therapy in HBeAg-negative CHB patients is no relation to the levels of ALT,HBV DNA,sex and age.更多还原