【摘要】 目的评估甲状腺腺瘤相关基因(THADA)与中国北方汉族人群2型糖尿病(T2DM)的相关性。方法以1 050例T2DM患者和1 030名糖耐量正常者(NGT)为研究对象,采用病例一对照研究设计,对THADA基因区的5个单核苷酸多态性(SNPs)位点:rs13026309、rs13029250、rs1 3022691、rs4952986、rs6739828进行基因分型,通过Logistic回归、线性回归分析等位基因变异与T2DM及其相关性状的关联。结果女性NGT人群在相加遗传模式下调整年龄、性别和BMI后,rs4952986位点与FIns(P=0.0095)、HOMAIR(P=0.0123)、HOMAβ(P=0.0089)相关。结论 THADA基因的rs4952986位点在中国北方汉族女性人群中,与胰岛素抵抗、胰岛素分泌功能相关,所选的5个位点未发现与T2DM相关。更多还原

【Abstract】 Objective To assess relationship of the single nucleotide polymorphisms(SNPs) at THADA locus with type 2 diabetes(T2DM) in northern Chinese Han population.Methods We genotyped 1050 patients with T2DM and 1030 control subjects for rs13026309,rs4952986,rs6739828, rsl3029250,rsl3022691 at THADA genetic locus.The associations between these SNPs and T2DM were examined by logistic regression on additive,dominant,and recessive genetic models after adjusting for age,gender,and body mass index(BMI).Linear regression was used to analyze the associations between SNPs and quantitative diabetes-related traits.Results No significant association was found between any one of rsl3026309,rs4952986,rs6739828,rsl3029250,rsl3022691 with T2DM.Rs4952986 was associated with fasting insulin concentration,insulin resistance(HOMA-IR) and beta cell function (HOMA-β) assessed by homeostasis model in women under additive model(Empirical P values=0.0095, 0.0123,0.0089,respectively).Conclusion A common genetic variation of THADA loci is associated with higher level of fasting insulin,insulin resistance and beta-cell function in Chinese female population. We do not replicate the association of THADA gene with type 2 diabetes.更多还原