【摘要】 为探讨油樟叶乙醇提取物的抗炎活性,建立了用二甲苯诱导小鼠耳肿胀、醋酸诱导小鼠毛细血管通透性增加和角叉菜胶诱导大鼠足肿胀的模型,并测定了角叉菜胶所致大鼠足炎性渗出液中前列腺素E2、组胺和5-羟色胺的含量。结果表明,油樟叶乙醇提取物能显著抑制二甲苯所致的小鼠耳肿胀、醋酸诱导的小鼠毛细血管通透性增加和角叉菜胶所致的大鼠足肿胀,且呈剂量依赖性,并能显著降低角叉菜胶所致大鼠足炎性渗出液中前列腺素E2、组胺和5-羟色胺的含量。证实油樟叶乙醇提取物具有较好的抗炎活性。更多还原

【Abstract】 The anti-inflammatory activity of the ethanol extract from Cinnamomum longepaniculatum leaves was investigated with three experimental models including the dimethyl benzene-induced ear edema in mice,the acetic acid-induced vascular permeability in mice and the carrageenan-induced paw edema in rats.The prostaglandin E2(PGE2),histamine and 5-hydroxytryptamine(5-HT) in exudates of paw edema induced by carrageenan in rats were also detected for the evaluation of anti-inflammatory activity of the ethanol extract. In result,the ethanol extract significantly inhibited the ear edema,and the capillary permeability and the paw edema with a dose-dependent relationship.The ethanol extract resulted in a dosedependent reduction of the levels of PGE2,histamine and 5-HT in the exudates of edema paw induced by carrageenin.These results demonstrated that the ethanol extract from C.longepaniculatum leaves has potential anti-inflammatory activity.更多还原