【摘要】 目的探讨孤立性轻度脑室扩张胎儿的产前诊断及临床预后,为临床遗传咨询和优生优育提供依据。方法回顾性分析并随访2006年8月至2008年12月南京医科大学苏州市立医院生殖与遗传中心产前B超诊断孤立性轻度脑室扩张的胎儿40例,记录其临床处理方式,随访B超及新生儿检查结果。结果 (1)40例病例中已有22例胎儿继续妊娠并分娩,1例出生时死亡,1例出生后4个月死亡,2例有发育异常,余18例胎儿娩出后CT或B超检查未见异常(81.8%,18/22)。(2)共15例病例进行了胎儿染色体检查,未见染色体异常。结论对于孤立性轻度脑室扩张的胎儿,建议行染色体检查;染色体正常的胎儿,应行多次B超复查,并建议进行胎儿MR I检查,无进行性加重且胎儿MR I无明显异常者其预后一般较好,在充分告知患者利弊的情况下,可以继续妊娠。更多还原

【Abstract】 0bjective To assess the outcome of fetuses with isolated mild ventriculomegaly,and to provide the scientific evidences for setting the preventive strategies.Methods 40 cases of fetal mild ventriculomegaly diagnosed by prenatal ultrasound(US) in our hospital were reviewed.Clinic treatment method,prenatal ultrasound results and fetal outcome were collected and retrospective analyzed.Results(1)Of these 40 cases,there were no positive diagnoses on neonatus CT or/and US in 18 of 22 mild cerebral ventriculomegaly(81.8%).(2)15 chromosome karyotype were normal.Conclusion The outcome of fetal isolated mild cerebral ventriculomegaly with a normal karyotype appears to be favorable.Follow up with ultrasound and fetal MRI should be suggested.更多还原