【摘要】 目的评价国产风疹减毒活疫苗(Rubella Attenuated Live Vaccine,RV)的保护效果,为完善RV免疫策略提供依据。方法采用系统评价方法,以风疹、免疫、效果为检索词,全面检索1994～2011年《中国期刊全文数据库》和《万方全文数据库》,对纳入文献相关信息进行分析。结果符合纳入标准的文献20篇,14篇是免疫学效果的研究,4篇是免疫持久性的研究,2篇是对保护效果进行了对照研究。对RV免疫学效果和保护效果系统评价显示,接种RV后血凝抑制抗体阳性率为97.3%～100.0%,IgG抗体阳性率为85.4%～100.0%;7年后抗体阳性率保持>90%;Meta分析疫苗的保护效果为77%。结论接种RV后,抗体阳性率高,并能保持较好的持久性和保护作用。更多还原

【Abstract】 Objective To review systematic immunology effect and protective efficacy of domestic rubella attenuated live vaccine and provide the basis for improving immunization strategy of rubella.Methods China national knowledge internet full text database(1994-2011)and Wanfang database(1994-2011)was searched with key words of rubella,vaccine,effect.Systematic review and metaanalysis were performed to analysis the selected literatures.Results 28 papers were involved.14 were studies on immunology efficacy of rubella vaccine,4 involved studies on immune persistent of rubella vaccine,2 were case-control studies about protective efficacy of rubella vaccine.The results of systematic review showed that the hemagglutination inhibition antibody positive rate was 97.3%-100.0%,the IgG antibody positive rate was 85.4%-100.0% and positive rate after 7 years remained above 90%.A meta-analysis showed that protective efficacy of rubella vaccine was 77%.Conclusion Domestic rubella attenuated live vaccine produced high-titer antibodies and maintained long-term protection against rubella.Rubella vaccine has protective effect in vaccinated group compare with unvaccinated.更多还原