【摘要】 目的了解现阶段山东省社区人群乙型肝炎(乙肝)病毒(Hepatitis B Virus,HBV)易感状态,为制定预防控制策略提供参考。方法 2006年9月,采用多阶段随机抽样的方法,抽取山东省12个县(市、区)1～59岁7601人作为调查对象,对所有调查对象进行问卷调查并采集血标本;用酶联免疫吸附试验检测乙肝病毒表面抗原(HBV Surface Antigen,HBsAg)、抗乙肝病毒表面抗原抗体(Antibody to HBsAg,Anti-HBs)和抗乙肝病毒核心抗原抗体(Antibody to HBV Core Antigen,Anti-HBc);HBV易感状态指经检测血清HBsAg、Anti-HBs和Anti-HBc均为阴性,采用权重调整法估算不同人群HBV易感率。结果山东省1～59岁社区人群HBV易感率为48.25%(95%可信区间为45.05%～51.46%)。15～59岁人群易感率(52.07%)高于1～4岁(26.79%)和5～14岁(31.51%)人群;农村地区人群易感率(49.65%)高于城市地区(40.53%),差异均有统计学意义(P<0.05)。未发现不同性别、地理区域人群HBV易感率差异有统计学意义(P>0.05)。结论山东省社区人群中不同年龄组人群HBV易感的实际意义不尽相同,青少年和成人中仍存在大量HBV易感人群,应加强该人群以接种乙肝疫苗为主的预防控制。更多还原

【Abstract】 Objective To explore hepatitis B virus(HBV)susceptibility status among the community-based population of Shandong province,and to provide scientific data for more effective prevention strategy.Methods 7601 targeted population aged 1～59 years were selected randomly by multistage from 12 counties of Shandong province in September of 2006.The interviews were carried out using a standard questionnaire.The blood samples were collected and detected for HBsAg,Anti-HBs and Anti-HBc by enzyme-linked immunosorbent assay(ELISA).HBV susceptibility is means to the negative of HBsAg,anti-HBs and anti-HBc.The weighted prevalence of HBV susceptibility was analyzed.Results HBV susceptibility rate among population aged 1-59 years was 48.25%(95%CI 45.05%-51.46%).The susceptibility rate was significantly higher among the targeted population who aged 15-59 years(52.07%)than those aged 1-4 years(26.79%)and 5-14 years(31.51%)(P<0.05).The rate was also significant higher in the rural areas(49.65%)than the urban area(40.53%)(P<0.05).No diffefences were found between the males and females,and among the population living in the eastern,western and central areas(P>0.05).Conclusions The actual signifance of HBV susceptibility is different in three age group among community-based population.There were still many adolescents and adults susceptible to HBV in Shandong province.The vaccination strategy for hepatitis B control should be further strengthened.更多还原