【摘要】 目的探讨在相近的原发性高血压(EH)发病的遗传背景下,环境因素对原发性高血压发生的影响。方法从57户高血压家系中,选取60个年龄相近、性别相同的同胞对,其中一人为原发性高血压患者,另一人为血压正常者,进行1∶1配对病例对照研究;应用多因素条件Logistic回归分析筛选原发性高血压的易患危险因素,数据分析采用SPSS 12.0统计软件。结果单因素分析结果显示,吸烟、饮酒、血糖、甘油三酯(TG)、胆固醇(CHOL)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、血钾、血纳、血钙在对照组与病例组之间差异均无统计学意义(P>0.05),仅体质指数(BM I)在对照组与病例组之间差异有统计学意义(P<0.05);多因素条件Logistic回归分析结果显示,BM I可能是原发性高血压的易患危险因素(OR=29.330,95%CI=2.594~331.613)。结论在相近的遗传条件下,BM I可能是原发性高血压的易患危险因素。更多还原

【Abstract】 Objective To investigate the effect of environmental risk factors on essential hypertension(EH) under the similar genetic background.Methods The study selected 60 sibs(one was hypertensive and the other was normotensive) for a paired case-control study.The data were analyzed with mulitple conditional logistic regression using SPSS 12.0 software.Results There was no statistical difference in smoking,drinking,blood fat,blood sugar,serum potassium,serum sodium,serum calcium between hypertensive and normotensive group(P>0.05).The hypertensive individuals had higher body mass index(BMI) than the corresponding normotensive individuals.BMI was a risk factor of EH(P<0.05) with an odds ratio of 29.330(95% confidence interval:2.594-331.613) from multiple conditional logistic regression.Conclusion BMI may be a risk factor of EH under similar genetic background.更多还原