【摘要】 目的探讨体重控制情况与新发糖尿病(DM)的关系。方法采用前瞻性研究方法,以江苏省多代谢异常和代谢综合征防治研究队列满足条件的人群为研究对象,比较随访体重控制在不同水平时DM的发病率,运用Cox比例风险模型分析体重控制情况与随访新发DM的关系。结果 3 168名研究对象中,有102例新发糖尿病患者;基线体重偏瘦组、正常组、超重组、肥胖组的DM累积发病率分别为3.4%、4.1%、5.5%、5.7%;基线体重正常、超重但随访转为肥胖的人群DM发病率分别为15.4%、7.2%,而随访体重保持或控制为正常的人群DM发病率仅为4.9%;多因素调整后,以体重保持正常的人群为对照组,基线体重正常但随访转肥胖的人群发生DM的RR为4.09,95%CI为1.75~9.54,基线体重肥胖随访仍为肥胖的人群发生DM的RR为2.89,95%CI为1.54~5.42。结论若随访人群的体重能有效控制,发生糖尿病的风险将会明显降低。更多还原

【Abstract】 Objective To investigate the relationship between weight control and the incidence of type 2 diabetes mellitus(T2DM).Methods Non-diabetic subjects were recruited from the program "Prevention of Multiple Metabolic Disorders and Metabolic Syndrom(MS) in Jiangsu Province"(PMMJS) to evaluate the incidence rate of DM in diferent weigth control groups.The relationship between weight control and the subsequent development of T2DM was evaluated with Cox ratio hazard model.Results During the follow-up period,102 subjects developed DM among 3 168 study subjects.The incidence rate of DM in lean,normal weight,oerweight,and obesity group was 3.4%,4.1%,5.5%,and 5.7%.The incidence rates of DM in the group with normal baseline weight and overweight but without weight control were 15.4%,7.2%,which were significantly higher than those who controlled weight during the follow-up period(4.9%).After adjusting for age,sex and other diabetes-related risk factors at baseline study and compared with the keeping normal weight group,the multivariable adjusted relative ratios(RRs)(95% confidence interval) for incident diabetes in the subjects with normal weight at baseline and then became obesity was 4.09(1.75-9.54).While in obese patients with uncontrolled weight was 2.89(1.54-5.42).Conclusion When the weight was effectively under control,the risk of developing T2DM could be reduced.更多还原