【摘要】 目的观察血浆P-选择素(P-selectin)及血清一氧化氮(NO)水平在急性冠脉综合征(ACS)患者中的变化,探讨其与急性冠脉综合征的关系。方法用ELISA方法测定60例急性冠脉综合征患者-急性心肌梗死(AMI)、不稳定型心绞痛(UAP)各30例,30例稳定型心绞痛患者(SAP)、30例体检健康者血浆P-selectin及血清NO水平。结果⑴急性冠脉综合征患者血浆P-selectin水平较稳定型心绞痛患者及健康对照组明显升高(P<0.01),⑵急性冠脉综合征患者血清NO水平较对照组明显降低(P<0.01)。⑶血清NO与血浆P-selectin水平成负相关(P<0.01),与高密度脂蛋白胆固醇(HDL-C)水平成正相关(P<0.05)。结论血浆P-selectin及血清NO水平对急性冠脉综合征的诊断有指导意义。更多还原

【Abstract】 Objective To observe the plasma P-selectin and serum nitric oxide levels in patients with acute coronary syndrome (ACS), and investigate its associations with ACS. Methods Enzyme-linked immunosorbent assay (ELISA) was used to measure plasma P-selectin and serum NO levels in patients with acute myocardial infarction (n=60), unstable angina pectoris (n=30) and stable angina pectoris (n=30), and the healthy individuals (n=30). Results (1) The plasma P-selectin levels in patients with ACS were increased significantly compared with those in patients with stable angina pectoris and the healthy individuals (P<0.01). (2) The serum NO levels in patients with ACS was significantly lower than the control group (P<0.01). (3) Serum NO levels was negatively associated with plasma P-selectin levels (P<0.01) and positively associated with high density lipoprotein cholesterol levels (P<0.05). Conclusion Plasma P-selectin and serum NO levels may be used to guide the diagnosis of the patients with acute coronary syndrome.更多还原