【摘要】 目的应用超声斑点追踪显像（STE）评价舒张性心力衰竭兔模型的左室二维应变及扭转运动的特点。方法 22只雄性新西兰兔随机分为两组:其中一组（12只）以肾上腹主动脉缩窄的方法建立舒张性心力衰竭模型;另一组为对照组（10只）。应用STE技术测量左室纵向（LS）、径向（RS）、圆周应变（CS）及左室扭转相关参数,并行左室导管及心肌病理学检查。结果 DHF组左室LS、RS减低,tPtw延迟,IUR减低。CS、Ptw无差异。IUR与tau呈负相关,Ptw与EF、dp/dt_max呈正相关。结论 STE可有效评价DHF兔左室的二维应变和扭转运动。更多还原

【Abstract】 Objective To assess left ventricular two-dimensional strain and twist in rabbit models with diastolic heart failure（DHF） by speckle tracking echocardiography（STE）.Methods Twenty-two male New Zealand rabbits were randomly divided into two groups:one group was used to establish DHF model by suprarenal abdominal aortic constriction（n= 12） and the other was as control group（n = 10）.Longitudinal（LS）,radial（RS）,circumferential strain （CS）and twist-related parameters were measured.Left ventricular catheterization and myocardial pathological examination were performed.Results In DHF group,LS and RS decreased,time to peak twist delayed and isovolumic untwisting rate decreased（P<0.01）.However,peak twist angle and CS didn’t change significantly（P>0.05）.And IUR correlated negatively to Tau.Ptw correlated positively to EF and dp/dt_max.Conclusions STE is useful in evaluating left ventricular two-dimensional strain and twist motion in rabbit model with DHF.更多还原